例句與造句

1. Due to its functional selectivity for the G protein pathway, 6'- GNTI functions as an tolerance.
2. Terms that describe this phenomenon are " functional selectivity ", " protean agonism ", or selective receptor modulators.
3. This functional selectivity is critical to prevent potential side effects and suggests that the theoretical risk of cardiac valvulopathy is very low.
4. S-40503 is a SARM that shows good functional selectivity for bone tissue, and has relatively little effect on muscle mass and no observable effect on the prostate gland.
5. It is also important to note that these observations were made in a number of different expression systems and therefore functional selectivity is not just an epiphenomenon of one particular expression system.
6. It's difficult to find functional selectivity in a sentence. 用functional selectivity造句挺難的
7. However, it shows 32-fold functional selectivity for activation of the ER? over the ER? ( EC 50 = 0.66 nM versus 19.4 nM, respectively ).
8. As such, its binding selectivity for the ER? over the ER? was 7-fold and its functional selectivity for the ER? over the ER? was between 10-and 13-fold.
9. When the subtype activated depends on the ligand that is bound to the GPCR, this is called functional selectivity ( also known as agonist-directed trafficking, or conformation-specific agonism ).
10. "' Functional selectivity "'( or  agonist trafficking,  biased agonism,  biased signalling, " ligand bias ", and  differential engagement ) is the receptor.
11. "' Functional selectivity "'posits that a ligand may inherently produce a mix of the classic characteristics through a single receptor isoform depending on the effector pathway coupled to that receptor.
12. It displays functional selectivity ( also known as " biased agonism " ) by strongly activating 5-HT 1A receptors in the postsynaptic prefrontal cortex while having little effect on somatodendritic autoreceptors in the raphe nucleus.
13. Consequently, cipralisant was reassessed as an H 3 receptor agonist in human and rat recombinant systems, showing functional selectivity and stimulating one type of G-protein coupled pathway while failing to activate other intracellular pathways.
14. It is a selective agonist for the androgen receptor, producing functional selectivity with effective dissociation of anabolic and androgenic effects, acting as a partial agonist for androgenic effects, but a full agonist for anabolic effects.
15. 25I-NBOMe presumably exhibits functional selectivity at the 5HT 2A receptor similar to other phenethylamine hallucinogens, activating the Phospholipase A2 signal cascade, which is responsible for the release of Thromboxane A2, triggering blood platelet aggregation.
16. The discovery of functional selectivity and that ligand-specific receptor conformations occur and can affect interaction of receptors with different second messenger systems may mean that drugs can be designed to activate some of the downstream functions of a receptor but not others.
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